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Take phendimetrazine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.Phendimetrazine is usually taken once a day (sustained release formula) or two to three times daily (immediate-release formula) before meals on an empty stomach.

Do not take phendimetrazine in the evening because it may cause insomnia.

Do not crush, chew, or open any “once-daily” phendimetrazine tablets or capsules. Swallow them whole.Never take more of this medication than is prescribed for you. Too much phendimetrazine could be very dangerous to your health.Store phendimetrazine at room temperature away from moisture and heat.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.Stop using phentermine and call your doctor at once if you have any of these serious side effects:chest pain, swelling in your ankles or feet, feeling light-headed, fainting, or feeling short of breath, even with mild exertion;fast or uneven heartbeat;unusual thoughts or behavior, feeling restless or confused; orincreased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).

Less serious side effects may be more likely to occur, such as:

feeling nervous or anxious;headache, dizziness, tremors;trouble sleeping (insomnia);dry mouth or an unpleasant taste in your mouth;diarrhea or constipation; oritching.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Before taking phentermine, tell your doctor if you are using any of the following drugs:

medicines to treat high blood pressure;insulin or diabetes medication you take by mouth;guanadrel (Hylorel), guanethidine (Ismelin);antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft); orantidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil).

If you are using any of these drugs, you may not be able to use phentermine, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect phentermine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Taking high doses of phentermine over long periods of time can cause severe skin problems, sleep problems (insomnia), personality changes, and feeling hyperactive or irritable.Take this medicine with a full glass of water.It is best to take phentermine on an empty stomach before breakfast, or at least 10 to 14 hours before bedtime.

Phentermine should be taken only for a short time, such as a few weeks.

Do not crush, chew, break, or open an extended-release capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.

You may have withdrawal symptoms when you stop using phentermine after using it over a long period of time. Do not stop using this medication suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

Do not take phentermine in the evening because it may cause sleep problems (insomnia).

Stop taking phentermine if you have increased hunger or if you otherwise think the medication is not working properly. Do not take more phentermine for an increased effect. Taking too much of this medication can cause serious, life-threatening side effects.

Phentermine may be habit-forming and should be used only by the person it was prescribed for. Keep track of how many pills have been used from each new bottle of this medicine. Phentermine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.Store phentermine at room temperature away from moisture and heat.

Taking phentermine together with other diet medications such as fenfluramine (Phen-Fen) or dexfenfluramine (Redux) can cause a rare fatal lung disorder called pulmonary hypertension. Do not take phentermine with any other diet medications without your doctor’s advice.