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Take chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.Do not crush, chew, or break the long-acting or sustained-release forms of this medication. Swallow them whole. If you are unsure of the formulation of the medicine, ask your pharmacist for help.

If you cannot swallow the tablets or capsules, look for a liquid form of the medication.

To ensure that you get a correct dose, measure the liquid forms of chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Do not take more of this medication than is recommended. An overdose of this medication can cause serious harm.

Do not take chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine for longer than 7 days in a row. If your symptoms do not improve, if they get worse, or if you have a fever, talk to your doctor.

Store chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine at room temperature away from moisture and heat.

Do not take chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

kidney disease,liver disease,diabetes,glaucoma,any type of heart disease or high blood pressure,thyroid disease,emphysema or chronic bronchitis, ordifficulty urinating or an enlarged prostate.

You may not be able to take chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

This medication passes into breast milk and may harm a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

If you are over 60 years of age, you may be more likely to experience side effects from chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine. You may require a lower dose of this medication.

Read the package label for directions or consult your doctor or pharmacist before treating a child with this medication. Children are more susceptible than adults to the effects of medicines and may have unusual reactions.

Use caution when driving, operating machinery, or performing other hazardous activities. Chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine.

Chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine is taken with any of these medications.

Serious side effects are unlikely to occur. Stop taking chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine and talk to your doctor or try another similar medication if you experience

dryness of the eyes, nose, and mouth;drowsiness or dizziness;blurred vision;difficulty urinating; orexcitation in children.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Do not take chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Do not take other over-the-counter cough, cold, allergy, diet, or sleep aids while taking chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine without first talking to your doctor or pharmacist. Other medications may also contain chlorpheniramine, phenyltoloxamine, phenylephrine, phenylpropanolamine, or other similar drugs. You may accidentally take too much of these medicines.

Chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine is taken with any of these medications.

Drugs other than those listed here may also interact with chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Use caution when driving, operating machinery, or performing other hazardous activities. Chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine.

Do not take more of this medication than is recommended. If your symptoms do not improve, or if they worsen, talk to your doctor.

Chlorpheniramine and phenyltoloxamine are antihistamines. They block the effects of the naturally occurring chemical histamine in the body. Chlorpheniramine and phenyltoloxamine prevent sneezing; itchy, watery eyes and nose; and other symptoms of allergies and hay fever.

Phenylephrine and phenylpropanolamine are decongestants. They constrict blood vessels (veins and arteries). This reduces the blood flow to certain areas and allows nasal and respiratory (breathing) passages to open up.

Chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine is used to treat nasal congestion and sinusitis (inflammation of the sinuses) associated with allergies, hay fever, and the common cold.

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Chlorpheniramine/phenyltoloxamine/phenylephrine/phenylpropanolamine may also be used for purposes other than those listed in this medication guide.

Before taking aspirin, chlorpheniramine, and dextromethorphan, talk to your doctor if you are taking any of the following medicines:

a diuretic (water pill);blood pressure medication;steroids (prednisone and others);seizure medication;oral diabetes medications;probenecid (Benemid, Probalan) or sulfinpyrazone (Anturane);medication used to prevent blood clots, such as clopidogrel (Plavix), dipyridamole (Persantine), and others;medication to treat irritable bowel syndrome;bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol); andsalicylates such as Disalcid, Doan’s Pills, Dolobid, Salflex, Tricosal, and others.

This list is not complete and there may be other drugs that can interact with aspirin, chlorpheniramine, and dextromethorphan. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.Aspirin should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Aspirin can cause a serious and sometimes fatal condition called Reye’s syndrome in children.Do not take this medication if you are allergic to aspirin, dextromethorphan, chlorpheniramine, or other antihistamines, or if you have:.a recent history of stomach or intestinal bleeding;a bleeding disorder such as hemophilia; oran allergy to an NSAID (non-steroidal anti-inflammatory drug) such as Advil, Motrin, Aleve, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.

Before taking aspirin, chlorpheniramine, and dextromethorphan, tell your doctor if you have:

heart disease, high blood pressure;history of heart attack, stroke or blood clots;a bleeding or blood clotting disorder such as hemophilia;diabetes;emphysema or chronic bronchitis;glaucoma;kidney disease;an enlarged prostate; orproblems with urination.

If you have any of these conditions, you may not be able to use this medication, or you may need a dosage adjustment or special tests during treatment.

Aspirin may be harmful to an unborn baby’s heart, and may also reduce birth weight or have other dangerous effects. Tell your doctor if you are pregnant or plan to become pregnant while you are taking aspirin.This medication may pass into breast milk and could harm a nursing baby. Do not use aspirin, chlorpheniramine, and dextromethorphan without telling your doctor if you are breast-feeding a baby.

Avoid drinking alcohol while you are taking this medication. Alcohol may increase your risk of stomach bleeding while taking aspirin, and can add to drowsiness caused by chlorpheniramine.This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.Avoid using other medicines that make you sleepy (such as pain medication, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety). Tell your doctor if you need to use any of these other medicines while you are taking aspirin, chlorpheniramine, and dextromethorphan.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor’s advice. Taking a stimulant together with cough or cold medicine can increase your risk of unpleasant side effects.

Do not use any other over-the-counter cough, cold, allergy, pain, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, cough suppressant, pain reliever, or fever reducer.

Avoid taking an NSAID (non-steroidal anti-inflammatory drug) while you are taking aspirin. NSAIDs include ibuprofen (Motrin, Advil), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), naproxen (Aleve, Naprosyn), and others.